Dr. Qasim Rasi, PhD 2009

Cilia and the Cell Cycle: Fundamentals revealed by Chlamydomonas reinhardtii.

Most of the cells in the human body are ciliated – they have tiny hair-like projections. Some of these cilia are tiny and immotile, healing while others are highly modified, nevertheless, they are critical to the proper functioning of the cell. Over the past dozen years, science has learned that a number of human diseases, including polycystic kidney diseases, Bardet-Beidl syndrome, and various forms of retinal degeneration are caused by defective cilia.

Research in the Quarmby lab is rooted in studies of calcium signaling and microtubule dynamics. Until recently, we were focused solely on understanding the mechanism by which cells shed their cilia (aka flagella) in response to stress. Through our work on the mechanism of deflagellation in the unicellular alga, Chlamydomonas, we discovered intriguing relationships between deflagellation, flagellar/ciliary assembly and the cell cycle. We continue to use the awesome power of Chlamydomonas genetics, biochemistry and cell biology to study deflagellation, but now we also study how cells reabsorb their cilia prior to cell division. This process is shown in the time-lapse movie to the right, by prior Quarmby lab Ph.D. student, Moe Mahjoub.
I started in the Quarmby lab in 2006, sildenafil during my third year of undergraduate studies at SFU and began graduate work in 2008. I completed my PhD in the Quarmby lab in 2013. Since then I have held positions in Curriculum Development at SFU and as a Teaching Fellow at Quest University, all the while retaining my involvement with the Quarmby lab. I am currently part of the team working on the Snow Algae project.

I was born and raised in North Vancouver, where I currently live with my young family. When I’m not teaching or doing science, I like riding my bike around the city or playing board games with friends.
I started in the Quarmby lab in 2006, medstore during my third year of undergraduate studies at SFU and began graduate work in 2008. I completed my PhD in the Quarmby lab in 2013. Since then I have held positions in Curriculum Development at SFU and as a Teaching Fellow at Quest University, visit web all the while retaining my involvement with the Quarmby lab. I am currently part of the team working on the Snow Algae project.

I was born and raised in North Vancouver, where I currently live with my young family. When I’m not teaching or doing science, I like riding my bike around the city or playing board games with friends.
I started in the Quarmby lab in 2006, order during my third year of undergraduate studies at SFU and began graduate work in 2008. I completed my PhD in the Quarmby lab in 2013. Since then I have held positions in Curriculum Development at SFU and as a Teaching Fellow at Quest University, purchase all the while retaining my involvement with the Quarmby lab. I am currently part of the team working on the Snow Algae project.

I was born and raised in North Vancouver, and currently live in Burnaby with my husband, Neill, and our two dogs, Linus and Lucy. When I’m not doing science, I like riding my bike around the city or playing cards or board games with friends.
I started in the Quarmby lab in 2006, order during my third year of undergraduate studies at SFU and began graduate work in 2008. I completed my PhD in the Quarmby lab in 2013. Since then I have held positions in Curriculum Development at SFU and as a Teaching Fellow at Quest University, purchase all the while retaining my involvement with the Quarmby lab. I am currently part of the team working on the Snow Algae project.

I was born and raised in North Vancouver, and currently live in Burnaby with my husband, Neill, and our two dogs, Linus and Lucy. When I’m not doing science, I like riding my bike around the city or playing cards or board games with friends.
I started in the Quarmby lab in 2006, healing my third year of undergraduate studies at SFU, treatment
and began graduate work in 2008. I completed my PhD in the Quarmby lab in 2013. Since then I have held positions in Curriculum Development at SFU and as a Teaching Fellow at Quest University, all the while retaining my involvement with the Quarmby lab. I am currently part of the team working on the Snow Algae project.

I was born and raised in North Vancouver, and currently live in Burnaby with my husband, Neill, and our two dogs, Linus and Lucy. When I’m not doing science, I like riding my bike around the city or playing cards or board games with friends.
After defending her MSc in 2009, help Jaime stayed on with us as a lab tech until Spring 2011. Since then she has been exploring some of her other passions – she is a fashion designer, a jeweller and a traveller. We hope to catch up with her at our next lab party.
After defending her MSc in 2009, help Jaime stayed on with us as a lab tech until Spring 2011. Since then she has been exploring some of her other passions – she is a fashion designer, a jeweller and a traveller. We hope to catch up with her at our next lab party.
I joined the Quarmby lab in 2006 as an MSc student. I completed my MSc in
August of 2009 after 3 wonderful years in the lab. In my thesis I addressed
specific questions related to three Neks: (i) NEK8 due to its role in cystic
kidney diseases (ii) NEK4 because of its unusual sub-cellular localisation
and (iii) CNK6 a potential link between cilia and the cell cycle. I
developed the tools necessary for the identification of NEK8 substrates. I
showed NEK4 localises to the distal end of the mother centriole and that
neither kinase activity, ailment nor the phosphorylation state of thr526 are
necessary for this localisation. I also demonstrated that CNK6, initially
identified in the flagellar proteome, does not localise to flagella and may
be essential for Chlamydomonas reinhardtii survival.

I took a year off from science following my time in the Quarmby lab to
further my career in the military and to work for the Olympics. I have since
rejoined the scientific community and am currently working towards my PhD
studying the role of a pancreas enriched transcription factor in the
regulation of insulin secretion and diabetes. I hope to be done my degree by
2014 and would eventually like to become a University Professor.
After defending her MSc in 2009, help Jaime stayed on with us as a lab tech until Spring 2011. Since then she has been exploring some of her other passions – she is a fashion designer, a jeweller and a traveller. We hope to catch up with her at our next lab party.
I joined the Quarmby lab in 2006 as an MSc student. I completed my MSc in
August of 2009 after 3 wonderful years in the lab. In my thesis I addressed
specific questions related to three Neks: (i) NEK8 due to its role in cystic
kidney diseases (ii) NEK4 because of its unusual sub-cellular localisation
and (iii) CNK6 a potential link between cilia and the cell cycle. I
developed the tools necessary for the identification of NEK8 substrates. I
showed NEK4 localises to the distal end of the mother centriole and that
neither kinase activity, ailment nor the phosphorylation state of thr526 are
necessary for this localisation. I also demonstrated that CNK6, initially
identified in the flagellar proteome, does not localise to flagella and may
be essential for Chlamydomonas reinhardtii survival.

I took a year off from science following my time in the Quarmby lab to
further my career in the military and to work for the Olympics. I have since
rejoined the scientific community and am currently working towards my PhD
studying the role of a pancreas enriched transcription factor in the
regulation of insulin secretion and diabetes. I hope to be done my degree by
2014 and would eventually like to become a University Professor.
M. Qasim Rasi was one of the first members of the SFU incarnation of the Quarmby lab. Qasim joined the lab as our “media person” in 2000, melanoma
he began in the lab part-time, meningitis
stayed for his undergraduate honours thesis research and then as a graduate student. He left with his Ph.D. in 2009 and the lab has not been the same since.

Writing up and defending his dissertation was not all that Qasim did in 2009. He also got married and moved to Edmonton. Elias was born in August 2010.

Currently Qasim is working towards an MBA Finance at the University of Alberta while working as a financial analyst and derivatives trader for a U.S. firm based in Edmonton. We always knew that Qasim was destined to be richer than the rest of us.